New studies on Dihydromyricetin powder
In the last article, we have already described the functions of dihydromyricetin, including liver protection and gallbladder, anti-tumor effect, antioxidant effect, and antibacterial effect. As researchers continue to deepen their research on dihydromyricetin, DHM will create greater value in the medical field.
1.Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety
Anxiety disorders are a group of mental disorders and a leading cause of disability in Western societies. Anxiety disorders, including generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorders, and phobias, typically have an early onset, run a chronic or relapsing course, cause substantial personal distress, impair social and occupational function, reduce quality of life, and impose a substantial economic burden . These disorders cost the U.S. more than $42 billion a year, comprising almost one-third of the country’s total mental health bill allotment .
This study demonstrated through a series of experiments that DHM treatment restored ATP and gephyrin expression, GABAergic transmission and synaptic function, and reduced anxiety-like behavior. The findings suggest a broader role for DHM in anxiolysis, GABAergic neurotransmission, and synaptic function. DHM is a potential candidate for pharmacotherapy of anxiety disorders.
2.Dihydromyricetin Reverses Thioacetamide-Induced Liver Fibrosis Through Inhibiting NF-κB-Mediated Inflammation and TGF-β1-Regulated of PI3K/Akt Signaling Pathway
As an important immune and metabolic organ of the human body, liver is vulnerable to damage from various causes, including hepatitis virus infection, alcohol and drug injury, autoimmune response and metabolic diseases .As a potent hepatotoxin, TAA-induced liver fibrosis is a well-recognised model for the development of liver damage, regenerative nodules and fibrosis, similar to human liver fibrosis . Numerous experiments have shown that long-term administration of TAA leads to proliferative liver nodules, liver fibrosis, hepatocellular adenomas and hepatocellular carcinoma.
This study demonstrated that DHM treatment improved damaged liver architecture and effectively reduced markers of oxidative stress and hepatotoxicity. More importantly, DHM reversed TAA-induced liver fibrosis by inhibiting NF-κB-mediated inflammation and apoptotic proteins downstream of the TGF-β1-regulated PI3K/Akt signaling pathway, which also suggests that DHM may be a potential Anti-chronic liver disease active substance.
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